INVESTIGATION OF ADDITIONAL RESPONSES CAUSED BY SAMPLE SURFACE TOPOGRAPHY IN PIEZORESPONSE FORCE MICROSCOPY MEASUREMENT

Investigation of additional responses caused by sample surface topography in piezoresponse force microscopy measurement

The purpose of this study is to elucidate the origin of the additional response signals arising from the surface topography of samples during piezoresponse force microscopy (PFM) measurements.Periodic mountain-shaped protrusions with triangular cross-sections were fabricated on the surface of a silicon single crystal, a material with no inherent pi

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MCU-independent Ca2+ uptake mediates mitochondrial Ca2+ overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy

Abstract Mitochondrial Ca2+ overload can mediate mitochondria-dependent cell death, a major contributor to several human diseases.Indeed, Duchenne muscular dystrophy (MD) is driven by dysfunctional Ca2+ influx across the sarcolemma that causes mitochondrial Ca2+ overload, organelle rupture, and muscle necrosis.The mitochondrial Ca2+ uniporter (MCU)

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